iron chelation afforded cardioprotection against h2o2-induced h9c2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives

Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: application of novel 3-hydroxy pyridine-4-one derivatives.

a study on the analgesic effects of four new derivatives of 3-hydroxy pyridine-4-one

derivatives of pyridine-4-one are iron chelators with various biological activities including antifungal, anti-malarial, antiviral, anti-inflammatory and analgesic activities. this study was aimed to evaluate the analgesic effect of four new derivatives of 3-hydroxy pyridine-4-one in animal models. acetic acid-induced writhing and formalin tests were used to assess the analgesic activity in mal...

A study on the analgesic effects of four new derivatives of 3-hydroxy pyridine-4-one

Derivatives of pyridine-4-one are iron chelators with various biological activities including antifungal, anti-malarial, antiviral, anti-inflammatory and analgesic activities. This study was aimed to evaluate the analgesic effect of four new derivatives of 3-hydroxy pyridine-4-one in animal models. Acetic acid-induced writhing and formalin tests were used to assess the analgesic activity in mal...

synthesis and antioxidant evaluation of novel schiff base derivatives of 3-hydroxy-pyridine-4-one containing hydrazone and oxime moiety at c-6 position of the pyridinone ring

Design and Synthesis of Novel Xyloketal Derivatives and Their Protective Activities against H2O2-Induced HUVEC Injury

In this work, we designed and synthesized a series of amide derivatives (1-13), benzoxazine derivatives (16-28) and amino derivatives (29-30) from xyloketal B. All 28 new derivatives and seven known compounds (14, 15, 31-35) were evaluated for their protection against H2O2-induced HUVEC injury. 23 and 24 exhibited more potential protective activities than other derivatives; and the EC50 values ...

Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives.

Coumarin derivatives are used as fluorescent dyes and medicines. They also have some notable physiological effects, including the acute hepatoxicity and carcinogenicity of certain aflatoxins, the anticoagulant action of dicoumarol, and the antibiotic activity of novobicin and coumerymycin A1. Because the number of drug resistant strains is increasing at present, the synthesis of new antibacteri...